منابع مشابه
Enkephalins and endorphins: the endogenous opiates.
The discovery of the opiate receptors in the central nervous system of man and subsequent identification of endogenous opiate-like ligands (enkephalins and endorphins) has provided a model for the analgesia, euphoria and addiction produced by the narcotics. In this article, the author reviews the background, biosynthesis and degradation, distribution, nociceptive transmission and analgesic effe...
متن کاملEnkephalins stimulate leukemia cell migration and surface expression of CD9.
Opioid peptides have been implicated in the regulation of tumor growth and biology; however, little attention has been given to the mechanisms that are involved. In this study we show that physiological concentrations of the endogenous opioid neuropeptide methionine-enkephalin (MET-ENK) and the synthetic enkephalins D-Ala2, Me-Phe4, Gly(ol)5 and D-Ala2, D-Leu5 are stimulants for the in vitro mi...
متن کاملEnkephalins in large bowel malignancy and in acute appendicitis.
Leucine and methionine enkephalins were measured by biological assay in normal colon, adenocarcinoma of the colon, carcinoma of the caecum, and in normal and inflamed appendix. Methionine enkephalin levels in both the adenocarcinomas and inflamed appendices were significantly higher than in normal controls. No significant change occurred in leucine enkephalin levels. The caecal tumours were ana...
متن کاملNaming Carcinogens
Interventional studies have demonstrated the impact of hyperglycemia on the development of vascular complications associated with type 2 diabetes, which underscores the importance of safely lowering glucose to as near-normal as possible. Among the current challenges to reducing the risk of vascular disease associated with diabetes is the management of body weight in a predominantly overweight p...
متن کاملRadioimmunoassay and characterization of enkephalins in rat tissues.
A highly sensitive and specific radioimmunoassay for three enkephalins (opiate-like pentapeptides) has been developed. The assay utilizes 12SI-labeled enkephalins and antisera raised in rabbits, to synthetic enkephalins coupled with glutaraldehyde to bovine serum albumin. These antisera show ~1% cross-reactivity between H,N-Tyr-Gly-GlyPhe-Met-OH ([MeVlenkephalin) and H,N-Tyr-Gly-Gly-PheLeu-OH (...
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ژورنال
عنوان ژورنال: Nature
سال: 1982
ISSN: 0028-0836,1476-4687
DOI: 10.1038/300310b0